Longevity Papers 2025-07-18

In this episode of Longevity Papers, we analyze groundbreaking research for biotech longevity scientists: JULY 2025 BREAKTHROUGHS: 1. Beyond the Pseudogene: p17/PERMIT as Mitochondrial Trafficking Protein (Albayram et al., Medical University of South Carolina, July 17) • Reclassification of "junk DNA" reveals mitochondrial chaperone critical for mitophagy\n • Loss accelerates sarcopenia and neurodegeneration • URL: https://pubmed.ncbi.nlm.nih.gov/40671432/ 2. RICTOR Regulates Longevity via Methionine-Mitophagy Axis (Motwani et al., National Institute of Immunology, July 10) • Vitamin B12-driven succinate accumulation activates mitophagy • Extends C. elegans lifespan through conserved nutrient-sensing pathway • URL: https://www.biorxiv.org/content/10.1101/2025.07.11.664440v1 3. Semaglutide Slows Epigenetic Aging in Humans (Corley et al., Weill Cornell, July 11) • GLP-1 agonist reduced GrimAge by 1.4-4.9 years in clinical trial • First evidence of epigenetic age reversal in HIV population\n • URL: https://www.medrxiv.org/content/10.1101/2025.07.09.25331038v1 4. ATF3 Deficiency in Vascular Aging (Nie et al., Huazhong University, July 11) • Terazosin stabilizes ATF3-ATG7 autophagy loop • Delays vascular smooth muscle cell senescence in aged mice • URL: https://pubmed.ncbi.nlm.nih.gov/40641410/ 5. Multi-Organ MRI Clocks Predict Mortality (MULTI Consortium, Columbia, July 12) • Brain/immune aging signatures emerge as top mortality predictors • 7-organ MRI analysis prioritizes 9 druggable targets • URL: https://www.medrxiv.org/content/10.1101/2025.07.10.25331263v1 6. Primate Rejuvenation via Engineered Stem Cells (Siddique et al., KAUST, June 27) • FOXO3-enhanced stem cells reversed multi-organ aging in monkeys • Reduced epigenetic age across brain/immune/reproductive systems • URL: https://pubmed.ncbi.nlm.nih.gov/40571786/ 7. Biomarker-Driven Geroprotector Discovery (Shindyapina et al., Harvard, June 30) • Platform identified selumetinib + vorinostat as lifespan-extenders • MEK/HDAC inhibitors extended healthspan in male mice • URL: https://www.biorxiv.org/content/10.1101/2025.06.26.661776v1 8. Engineered Telomerase RNA Therapy (Nagpal + Agarwal, Boston Children's, June 28) • Synthetic TERC extended telomeres in patient-derived stem cells • Solved delivery challenges for telomerase therapy • URL: https://pubmed.ncbi.nlm.nih.gov/40579489/ 9. ADIOL: Dietary Restriction's Neuroprotective Metabolite (Guijarro-Hernandez et al., UCSF, June 29) • Key mediator of calorie restriction benefits • Rescues APOE4-induced cellular stress • URL: https://www.biorxiv.org/content/10.1101/2025.06.25.661551v1 10. Mitochondrial Stress Response Modulator FIP1L1 (Li et al., EPFL, June 26) • Genetic mapping reveals conserved UPRmt regulator • Links mitochondrial proteostasis to longevity pathways • URL: https://www.biorxiv.org/content/10.1101/2025.06.26.661693v1 For full papers and daily longevity updates: https://longevitypapers.com Keywords: longevity research, aging biomarkers, epigenetic clocks, mitophagy, stem cell therapy, telomeres, geroprotectors, dietary restriction, mitochondrial health, neurodegeneration